منابع مشابه
Is High roughput Glycomics Possible?
The role of glycosylation and their biological functions whether as free oligosaccharides or glycoconjugates has been made possible by the recent advancements in the analyses of these compounds. The heterogeneity and the large structural diversity have made oligosaccharide analysis significantly more difficult than other biopolymers. The next stage of development is to achieve high throughput a...
متن کاملHigh-Throughput Analysis and Automation for Glycomics Studies
This review covers advances in analytical technologies for high-throughput (HTP) glycomics. Our focus is on structural studies of glycoprotein glycosylation to support biopharmaceutical realization and the discovery of glycan biomarkers for human disease. For biopharmaceuticals, there is increasing use of glycomics in Quality by Design studies to help optimize glycan profiles of drugs with a vi...
متن کاملGlycomics meets genomics, epigenomics and other high throughput omics for system biology studies.
Majority of eukaryotic proteins are glycosylated and their glycan moieties have numerous important structural, functional and regulatory roles. Because of structural complexity of glycans and technological limitations glycomics, and particularly glycoproteomics was not able to follow rapid progress in genomics and proteomics over last 30 years. However, the field of glycan has been progressing ...
متن کاملHigh throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.
Despite recent advances in our understanding of the significance of the protein glycosylation, the throughput of protein glycosylation analysis is still too low to be applied to the exhaustive glycoproteomic analysis. Aiming to elucidate the N-glycosylation of murine epidermis and dermis glycoproteins, here we used a novel approach for focused proteomics. A gross N-glycan profiling (glycomics) ...
متن کاملIs High Frequency Analog DFT Possible?
Design For Test (DFT) means altering a circuit design to make it more testable. DFT for high frequency (>lOO MHz) analog integrated circuits seems destined to be limited to looparound testing and other such end-to-end test methods. Any circuitry used to modify, monitor, or inject signals into the middle of such circuits inevitably impacts the function’s performance greatly much more than for lo...
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ژورنال
عنوان ژورنال: Mass Spectrometry
سال: 2013
ISSN: 2187-137X
DOI: 10.5702/massspectrometry.s0016